common adverse effects of anti tubercular drugs and management

as given in DOTS_Plus_Guidelines_Jan2010.pdf 
AMINOGLYOCIDES :- KANAMYCIN
-ototoxicity
-nephrotoxicity
-vertigo
-electrolyte imbalance


QUINOLONES:- OFLOXACIN
-photosensitivity
-tendinopathies
-skin rash
-arthalgia
-cardiotoxicity
-diarrhoea


ETHAMBUTOL
-optic neuritis
leads to visual disturbances, colour blindness


PYRAZINAMIDE
-Arthralgia
Hyperuricaemia
• Hepatitis
• Pruritis with or without rash


ETHIONAMIDE

-Psychiatric: hallucination and depression
• Hepatitis
Hypothyroidism and goitre with prolonged administration
Gynaecomastia,menstrual disturbances, impotence, acne, headache, and peripheral neuropathy


CYCLOSERINE

-CNS: dizziness, slurred speech, convulsions, headache, tremor, and insomnia
• Psychiatric: confusion, depression, altered behaviour, and suicidal tendency
• Hypersensitivity reaction


PAS
-Gastro-intestinal: anorexia, nausea, vomiting, and abdominal discomfort
• Skin rash
• Hepatic dysfunction
Hypokalemia
Hypothyroidism and goitre with prolonged administration

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